Diagnostics

Diagnostics: timeline of key events

Bordet was a Belgian physician, immunologist and microbiologist. He is best known for winning the 1919 Nobel Prize for his discovery of two components in the blood - antibodies and complement proteins - that help destroy invading bacteria. They do this by rupturing the cell walls of the bacteria, a process known as bacteriolysis. Bordet made the discovery in 1895. He subsequently found, in 1898, that red blood cells from one animal species injected into another get destroyed by haemolysis - a process analogous to bacteriolysis. His research laid the foundation for the development of diagnostic tests that looked for antibodies in the blood to detect infectious agents. The first one was for typhoid, developed in 1896.1870-06-13T00:00:00+0000 Yalow shared the 1977 Nobel Prize for Medicine for the development of radioimmunoassay diagnostic tests to measure the concentration of hormones, vitamins, viruses, enzymes, drugs and other substances. 1921-07-19T00:00:00+0000Ames developed a biological test to quickly identify whether or not a chemical compound is a potential carcinogen. Bacteria are exposed to the test substance and allowed to multiply. 1928-12-16T00:00:00+0000Bordet was a Belgian physician, immunologist and microbiologist. He is best known for winning the 1919 Nobel Prize for his discovery of two components in the blood - antibodies and complement proteins - that help destroy invading bacteria. They do this by rupturing the cell walls of the bacteria, a process known as bacteriolysis. Bordet made the discovery in 1895. He subsequently found, in 1898, that red blood cells from one animal species injected into another get destroyed by haemolysis - a process analogous to bacteriolysis. His research laid the foundation for the development of diagnostic tests that looked for antibodies in the blood to detect infectious agents. The first one was for typhoid, developed in 1896. 1961-04-06T00:00:00+0000T. Nogtomi, H. Okayama, H. Masubuchi, T. Yonekawa, K. Wantabe, N. Amino, T. Hase, 'Loop-mediated isothermal amplification', Nucleic Acids Research, 28/12 (2000), e63.2000-06-15T00:00:00+0000Yalow was an American medical physicist who shared the 1977 Nobel Prize for Medicine for the development of radioimmunoassay (RIA) technique. RIA uses two reagents. One is a radioisotope atom bound to a molecule of the target substance and the other is an antibody that will bind to the target substance when the two are in contact. Measurements are taken of the initial radioactivity of the mixture which is then added to a measured quantity of fluid, such as blood, that contains low concentrations of an unknown target substance. The test takes advantage of the fact that antibodies known to prefer to attach to non-radioactive molecules. Measurements are taken of the reduction in radioactivity of the antibody reagent to calculate the concentration of the target substance. The RIA method is now an important component in diagnostic tests, being used to measure the concentration of hormones, vitamins, viruses, enzymes, drugs and other substances. 2011-05-30T00:00:00+0000The test hunts for 16 gene that regularly arise in cancer and 8 proteins released by tumours. It was trialled in 1,005 patients with cancers of the ovary, liver, stomach, pancreas, oesophagus, colon, lung or breast that had not yet spread to other tissues. J.D. Cohen et al, Detection and localization of surgically resectable cancers with a multi-analyte blood test', Science, 18 Jan 2018, eaar3247, DOI: 10.1126/science.aar3247 2018-01-17T00:00:00+0000
Date Event People Places
13 Jun 1870Jules Bordet was born in Soignies, BelgiumBordetPasteur Institute
19 Jul 1921Rosalyn Yalow was born in New York NY, USAYalowVeterans Administration Hospital
16 Dec 1928Bruce N Ames was bornAmesUniversity California Berkeley
6 Apr 1961Jule Bordet diedBordetPasteur Institute
15 Jun 2000New simpler and cheaper PCR method published opening possibility for use in middle to low-income countriesNogtomi, Okayama, Masubuchi, Yonekawa, Wantabe, AminoUniversity of Tokyo, Osaka University, Eiken Chemical Co
30 May 2011Rosalyn Yalow diedYalowVeterans Administration Hospital
17 Jan 2018Blood test detecting mutated DNA and proteins released by tumours shown to pick up early signs of 8 common cancersCohen, Yuxuan Wang, Thoburn, Afsari, Danilova. Douville, Javed, Wong, Mattox, Hruban, Wolfgang, Goggins, Molin, Wang, Roden, Klein, Ptak, Dobbyn, Schaefer, Silliman, Popoli, Vogelstein, Browne, Schoen, Brand, Tie, Gibbs, Wong, Mansfield, Jen, Hanash, FalcJohns Hopkins University

13 Jun 1870

Jules Bordet was born in Soignies, Belgium

19 Jul 1921

Rosalyn Yalow was born in New York NY, USA

16 Dec 1928

Bruce N Ames was born

6 Apr 1961

Jule Bordet died

15 Jun 2000

New simpler and cheaper PCR method published opening possibility for use in middle to low-income countries

30 May 2011

Rosalyn Yalow died

17 Jan 2018

Blood test detecting mutated DNA and proteins released by tumours shown to pick up early signs of 8 common cancers