Timeline of key events in biotechnology

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J. S. Gootenberg, O.O. Abudayyeh, J. W. Lee, et al, 'Nucleic acid detection with CRISPR-Cas13a/C2c2', Science, 13 April 2017, eaam9321, DOI: 10.1126/science.aam9321 2017-04-13T00:00:00+0000G. Fontana, J. Gershlak, M. Adamski, J-S Lee, S. Matsumoto, H. D. Le, B. Binder, J. Wirth, G. Gaudette, W. L. Murphy, 'Decellularized Plants: Biofunctionalized Plants as Diverse Biomaterials for Human Cell Culture', Advanced Healthcare Materials, DOI: 10.1002/adhm.2017700382017-04-19T00:00:00+0000Collaborative research carried out by scientists at University of Edinburgh, University College London and Imperial College. 2017-04-20T00:00:00+0000The experiment was carried out by scientists at Sichuan University, Temple University and the University of Pittsburgh. It was published in C. Yin, et al, 'In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models', Molecular Therapy, 25/5 (2017), 1168-86.2017-05-13T00:00:00+0000The molecular structure of vancomycin was altered to enhance its attack on bacteria cell walls and have three mechanisms of attack so as to prevent bacteria developing resistance. A. Okano el al., 'Peripheral modifications of vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics,' PNAS (2017), oi/10.1073/pnas.1704125114 2017-05-31T00:00:00+0000The drug CTL019 (tisagenlecleucel) was developed by Novartis. Treatment involves removing T cells from the patient and genetically modifying them to increase their capacity to bind to tumour cells in order to get the immune sytem to attack the tumours. It is targeted at children and young adults from three to 25 years old who have not responded to traditional treatments.2017-07-12T00:00:00+0000M. Hong, N. Marti-Gutierrez, S-W Park, et al, 'Correction of a pathogenic gene mutation in human embryos', Nature, doi:10.1038/nature233052017-08-02T00:00:00+0000The drug Kymriah (tisagenlecleucel) is the first gene therapy to become available in the US. 2017-08-30T00:00:00+0000UK scientists modified 41 embryos shortly after fertilisation. N.M.E. Fogarty et al, 'Genome editing reveals a role for OCT4 in human embryogenesis', Nature, doi:10.1038/nature240332017-09-20T00:00:00+0000227 patient study showed drug from Alnylam Pharmaceuticals had benefits for rare hereditary disorder - ATTR amyloidosis with polyneuropathy, a rare disorder.2017-09-20T00:00:00+0000L. Xu, et al, 'Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques', Science, 20 September 2017, Science, 20 Sep 2017, eaan8630, DOI: 0.1126/science.aan86302017-09-20T00:00:00+0000The drug, a form of immunotherapy, is a PDL1 checkpoint inhibitor.2017-09-20T00:00:00+0000
Date Event People Places Sciences
13 Apr 2017CRISPR shown to be sensitive diagnostic tool for detecting single target of DNA or RNA moleculeAbudayyeh, Bhattacharyya, Collins, Daringe, Donghia, Dy, Essletzbichler, Freije, Hung, Joung, Koonin, Lee, Livny, Myhrvold, Regev, Sabeti, Gootenberg, Verdine, ZhangBroad Institute, Massachusetts Institute of Technology, Harvard University, Howard Hughes Medical Institute CRISPR-Cas9, Gene editing
Apr 2017Researchers at University of Washington-Madison demonstrated the possibility of growing skin, bone marrow and blood vessels using plant scaffolds with stem cells University of Washington-Madison, Olbrich Botanical GardensStem Cells
20 Apr 2017Diabetes research using transgenic mice shows the protein P2X7R plays important role in inflammation and immune system offering new avenue for treating kidney diseaseMenziesUniversity of Edinburgh, University College London, Imperial CollegeImunology, Transgenic animals
13 May 2017Research published demonstrating how CRISPR-CAS9 can be used to eliminate HIV in infected mice. Yin, Zhang, Qu, Chang, Putatunda, Xiao, Li, Zhao, Dhai, Qin, Mo, Young, Khalili, HuTemple University, University of Pittsburgh, Sichuan UniversityCRISPR-Cas9, Gene editing
31 May 2017Scientists report successfully re-engineering old antibiotic for combatting superbugsOkano, BodgerScripps Research InstituteAntimicrobial resistance, Antibacterial agents
12 Jul 2017US FDA Oncologic Drugs Advisory Committee recommended the approval of the first adoptive cell therapy (CAR-T cell therapy) for B cell acute leukaemia Novartis, University of PennsylvaniaCancer immunotherapy, Oncology, Adoptive cell therapy, Gene therapy
2 Aug 2017Research published demonstrating possibility of editing gene defect in pre-implanted human embryos for preventing inherited heart diseaseHong, Marti-Gutierrez, Park, Mitalipov, Kaul, Kim, Amato, BelmonteOregon Health & Science University, Salk Institute, Center for Genome Engineering, Seoul National University, China National GeneBank,CRISPR-Cas9, Reproduction, Cardiovascular, Gene editing
30 Aug 2017USA FDA approved CAR-T therapy for certain pediatric and young adult patients with a form of acute lymphoblastic leukemia Novartis, University of PennsylvaniaCancer immunotherapy, Oncology, Adoptive cell therapy, Gene therapy
Sep 2017DNA of human embryos edited using CRISPR-Cas9 to study cause of infertilityFogarty, McCarthy, Snijders, Powell, Kubikova, Blakeley, Lea, Elder, Wamaitha, Kim, Maciulyte, Kleinjung, Kim, Wells, Vallier, Bertero, Turner, NiakanFrancis Crick Instiitute, Cambridge University, Oxford University, Seoul National UniversityCRISPR-Cas9, Gene editing, Reproduction
20 Sep 2017Positive results reported from clinical trial with RNAi drug AlynlamRNA interference
20 Sep 2017Combination of three monoclonal antibodies reported to protect monkeys from HIV Xu, Pegu, Rao, Doria-Rose, Beninga, McKee, Lord, Wei, Deng, Louder, Schmidt, Mankoff, Wu, Asokan, Beil, Lange, Leuschner, Kruip, Sendak, Kwon, Zhou, Chen, Bailer, Wang, Choe, Tartaglia, Barouch, O’Dell, Todd, Burton, Roederer, Connors, Koup, Kwong, YangSanhofi, National Institute of Allergy and Infectious Disease, Harvard University, Massachusetts Institute of Technology, Scripps Research Institute, Monoclonal antibodies, Infectious diseases
20 Sep 2017Nivolumab (Opdivo®) made available for NHS patients with advanced lung cancer Honko, FreemanMedarex, Bristol-Myers Squibb, Ono PharmaceuticalImmune checkpoint inhibitors, Immunotherapy, Monoclonal antibodies

13 Apr 2017

CRISPR shown to be sensitive diagnostic tool for detecting single target of DNA or RNA molecule

Apr 2017

Researchers at University of Washington-Madison demonstrated the possibility of growing skin, bone marrow and blood vessels using plant scaffolds with stem cells

20 Apr 2017

Diabetes research using transgenic mice shows the protein P2X7R plays important role in inflammation and immune system offering new avenue for treating kidney disease

13 May 2017

Research published demonstrating how CRISPR-CAS9 can be used to eliminate HIV in infected mice.

31 May 2017

Scientists report successfully re-engineering old antibiotic for combatting superbugs

12 Jul 2017

US FDA Oncologic Drugs Advisory Committee recommended the approval of the first adoptive cell therapy (CAR-T cell therapy) for B cell acute leukaemia

2 Aug 2017

Research published demonstrating possibility of editing gene defect in pre-implanted human embryos for preventing inherited heart disease

30 Aug 2017

USA FDA approved CAR-T therapy for certain pediatric and young adult patients with a form of acute lymphoblastic leukemia

Sep 2017

DNA of human embryos edited using CRISPR-Cas9 to study cause of infertility

20 Sep 2017

Positive results reported from clinical trial with RNAi drug

20 Sep 2017

Combination of three monoclonal antibodies reported to protect monkeys from HIV

20 Sep 2017

Nivolumab (Opdivo®) made available for NHS patients with advanced lung cancer