Donall Thomas: Timeline of key events

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Thomas shared the 1990 Nobel Prize for Medicine for 'discoveries concerning organ and cell transplantation in the treatment of human disease.'1920-03-15T00:00:00+0000ED Thomas, HL Lochte, WC Lu, JW Ferrebee, 'Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy'. The New England Journal of Medicine, 257 (J.W. (12 September 1957), 491–6.1957-01-09T00:00:00+00001959-01-01T00:00:00+0000Thomas, K R, Folger, K R, Capecchi, M R, 'High frequency targeting of genes to specific sites in the mammalian genome,' Cell, 44 (1986), 419–28. 1986-02-14T00:00:00+0000Capecchi, M, 'Site-directed mutagenesis by gene targeting in mouse embyo-derived stem cells', Cell, 51/3 (1987), 503-12.1987-11-06T00:00:00+0000Mansour, S L, Thomas, K R, Capecchi, M R, 'Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes', Nature, 336 (1988): 348–52.1988-11-01T00:00:00+0000Thomas shared the 1990 Nobel Prize for Medicine for 'discoveries concerning organ and cell transplantation in the treatment of human disease.'2012-10-20T00:00:00+0000
Date Event People Places Sciences
15 Mar 1920E Donnall Thomas was born in Mart TX, USAThomasFred Hutchinson Cancer Research CenterTransplantaion, Immunology
Jan 1957First report of bone marrow transplants performed in human (cancer) patientsThomas, Lochte, Lu, FerrebeeBassett Medical CenterStem cells
1959Experiments in mice prove the existence of resident blood stem cells in marrowThomas Bassett Medical CenterStem cells
14 Feb 1986Gene targeting technique used to correct defective gene in the chromosome of a mammalian cellThomas, Folger, CapecchiUniversity of UtahGene editing
6 Nov 1987Publication of gene targeting technique for targetting mutations in any geneThomas, CapecchiUniversity of UtahGene editing, Transgenic animals
Nov 1988Oncogene disrupted in mice using gene targeting technologyMansour, Thomas, CapecchiUniversity of UtahGene editing
20 Oct 2012E Donnall Thomas diedThomasFred Hutchinson Cancer Research CenterTransplantaion, Immunology

15 Mar 1920

E Donnall Thomas was born in Mart TX, USA

Jan 1957

First report of bone marrow transplants performed in human (cancer) patients

1959

Experiments in mice prove the existence of resident blood stem cells in marrow

14 Feb 1986

Gene targeting technique used to correct defective gene in the chromosome of a mammalian cell

6 Nov 1987

Publication of gene targeting technique for targetting mutations in any gene

Nov 1988

Oncogene disrupted in mice using gene targeting technology

20 Oct 2012

E Donnall Thomas died