Cambridge University: Timeline of key events

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Campath-1G is humanised, resulting in Campath-1H. It is accomplished with technology developed by Greg Winter.1988-01-01T00:00:00+0000This patent is filed on the basis of work reported in M Brüggeman, HM Caskey, C Teale, H Waldmann, Williams, Surani, and MS Neuberger, A repertoire of monoclonal antibodies with human heavy chains from transgenic mice, Proc Natl Acad Sci USA, 86 (Sept 1989), 6709-13. 1988-01-01T00:00:00+0000Hodgkin shared the 1963 Nobel Prize for Medicine for 'discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane.'1998-12-20T00:00:00+00002009-01-01T00:00:00+00002012-01-01T00:00:00+0000Huxley was and English physiologist an biophysicist who helped uncover the mechanism of muscle contraction in 1954 through experiments on the giant axon of the Atlantic Squid. His study of muscle fibres was helped by his development of interference microscopy. Huxley shared the Nobel Prize for Medicine in 1963 for 'discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane'. 2012-05-30T00:00:00+0000Sharon Peacock and Julian Parkhill together with other researchers from the University of Cambridge and the Wellcome Trust Sanger Institute used whole genome sequencing to trace the spread of an outbreak of meticillin resistant Staphylococcus aureus (MRSA) in Rosie Hospital's special care baby unit. Prospective sequencing then led them to screen staff and identify the potential source of infection. The researchers reported that the cost of DNA sequencing for the infection was half of the 10,000 pounds spent by the hospital to combat the outbreak of MRSA.2012-06-01T00:00:00+0000Granted by European regulatory authorities.2013-09-17T00:00:00+0000The first to determine the DNA sequence of insulin, Sanger proved proteins have a defined chemical composition. He was also pivotal to the development of the dideoxy chain-termination method for sequencing DNA molecules, known as the Sanger method. This provided a breakthrough in the sequencing of long stretches of DNA in terms of speed and accuracy and laid the foundation for the Human Genome Project.2013-11-19T00:00:00+0000S. Ellys Harrison, B. Sozen, N. Christodoulou, C. Kyprianou, M. Zernicka-Goetz, 'Assembly of embryonic and extra-embryonic stem cells to mimic embryogenesis in vitro', Science, DOI: 10.1126/science.aal1810 2017-03-03T00:00:00+0000UK scientists modified 41 embryos shortly after fertilisation. N.M.E. Fogarty et al, 'Genome editing reveals a role for OCT4 in human embryogenesis', Nature, doi:10.1038/nature240332017-09-20T00:00:00+0000
Date Event People Places Sciences
1988Campath-1H is created - the first clinically useful humanised monoclonal antibody.Winter, Waldmann, Reichmann, ClarkCambridge University, Laboratory of Molecular BiologyMonoclonal antibodies, Recombinant DNA, Campath
1988Patent application filed for a method to create transgenic mice for the production of human antibodiesBruggeman, Caskey, Neuberger, Surani, Teale, Waldmann, WilliamsLaboratory of Molecular Biology, Babraham Institute, Cambridge UniversityMonoclonal antibodies, gene cloning, transgenic animals
20 Dec 1998Alan Lloyd Hodgkin diedHodgkinCambridge UniversityNeuroscience
2009Lasker Prize awarded to John Gurdon and Shinya Yamanaka for discoveries in nuclear reprogramming. Yamanaka is also awarded the Gairdner PrizeGurdon, YamanakaCambridge University, Kyoto UniversityStem cells
2012John Gurdon and Shinya Yamanaka win the Nobel Prize in Physiology or Medicine for the discovery that mature cells can be reprogrammed to become pluripotent stem cellsGurdon, YamanakaCambridge University, Kyoto UniversityStem cells
30 May 2012Andrew F Huxley diedHuxleyCambridge University, University College LondonCell, Neuroscience
Jun 2012DNA sequencing helps identify the source of an MRSA outbreak in a neornatal intensive care unitPeacock, ParkhillCambridge University, Wellcome Trust Sanger InstituteDNA Sequencing
Sep 2013Campath-1H gains marketing approval for the treatment of MS.Waldmann, Compston, ColesCambridge UniversityCampath
19 Nov 2013Sanger, the inventor of DNA sequencing, died at the age of 95SangerCambridgeDNA Sequencing
3 Mar 2017Cambridge scientists report the development of an aritificial mouse embryo using stem cells University of CambridgeStem cells, Reproduction
Sep 2017DNA of human embryos edited using CRISPR-Cas9 to study cause of infertilityFogarty, McCarthy, Snijders, Powell, Kubikova, Blakeley, Lea, Elder, Wamaitha, Kim, Maciulyte, Kleinjung, Kim, Wells, Vallier, Bertero, Turner, NiakanFrancis Crick Instiitute, Cambridge University, Oxford University, Seoul National UniversityCRISPR-Cas9, Gene editing, Reproduction

1988

Campath-1H is created - the first clinically useful humanised monoclonal antibody.

1988

Patent application filed for a method to create transgenic mice for the production of human antibodies

20 Dec 1998

Alan Lloyd Hodgkin died

2009

Lasker Prize awarded to John Gurdon and Shinya Yamanaka for discoveries in nuclear reprogramming. Yamanaka is also awarded the Gairdner Prize

2012

John Gurdon and Shinya Yamanaka win the Nobel Prize in Physiology or Medicine for the discovery that mature cells can be reprogrammed to become pluripotent stem cells

30 May 2012

Andrew F Huxley died

Jun 2012

DNA sequencing helps identify the source of an MRSA outbreak in a neornatal intensive care unit

Sep 2013

Campath-1H gains marketing approval for the treatment of MS.

19 Nov 2013

Sanger, the inventor of DNA sequencing, died at the age of 95

3 Mar 2017

Cambridge scientists report the development of an aritificial mouse embryo using stem cells

Sep 2017

DNA of human embryos edited using CRISPR-Cas9 to study cause of infertility