Cambridge University: Timeline of key events

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The first to determine the DNA sequence of insulin, Sanger proved proteins have a defined chemical composition. He was also pivotal to the development of the dideoxy chain-termination method for sequencing DNA molecules, known as the Sanger method. This provided a breakthrough in the sequencing of long stretches of DNA in terms of speed and accuracy and laid the foundation for the Human Genome Project.2013-11-19T00:00:00+0000S. Ellys Harrison, B. Sozen, N. Christodoulou, C. Kyprianou, M. Zernicka-Goetz, 'Assembly of embryonic and extra-embryonic stem cells to mimic embryogenesis in vitro', Science, DOI: 10.1126/science.aal1810 2017-03-03T00:00:00+0000UK scientists modified 41 embryos shortly after fertilisation. N.M.E. Fogarty et al, 'Genome editing reveals a role for OCT4 in human embryogenesis', Nature, doi:10.1038/nature240332017-09-20T00:00:00+0000The patient received a stem-cell transplant that replaced their white blood cells with HIV-resistant versions. The cells were taken from a donor who had two copies of a mutation in the CCR5 gene that confers resistance to HIV infection. The CCR5 gene codes for a receptor on white blood cells involved in the body's immune response. HIV normally binds to these receptors and attacks the cell. By removing the gene the receptors stop working normally. The patient was given the treatment as part of therapy for blood cancer. He was able to stop taking antiretroviral drugs after 16 months, and 18 months later had no sign of the virus. The research was published in RK Gupta, et al, Nature (2019), DOI 10.1038/s41586-019-1027-42019-03-05T00:00:00+0000
Date Event People Places Sciences
19 Nov 2013Sanger, the inventor of DNA sequencing, died at the age of 95SangerCambridgeDNA Sequencing
3 Mar 2017Cambridge scientists report the development of an aritificial mouse embryo using stem cells University of CambridgeStem cells, Reproduction
Sep 2017DNA of human embryos edited using CRISPR-Cas9 to study cause of infertilityFogarty, McCarthy, Snijders, Powell, Kubikova, Blakeley, Lea, Elder, Wamaitha, Kim, Maciulyte, Kleinjung, Kim, Wells, Vallier, Bertero, Turner, NiakanFrancis Crick Instiitute, Cambridge University, Oxford University, Seoul National UniversityCRISPR-Cas9, Gene editing, Reproduction
5 Mar 2019Second patient reported free of HIV after receiving stem-cell therapyGuptaUniversity of CambridgeStem cells, Gene therapy

19 Nov 2013

Sanger, the inventor of DNA sequencing, died at the age of 95

3 Mar 2017

Cambridge scientists report the development of an aritificial mouse embryo using stem cells

Sep 2017

DNA of human embryos edited using CRISPR-Cas9 to study cause of infertility

5 Mar 2019

Second patient reported free of HIV after receiving stem-cell therapy