Harvard University: Timeline of key events

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Pincus was a biologist. He first came to public attention in 1934 when he announced the creation of baby rabbits with in vitro fertilisation. His technique involved the removal of an ovum from the mother rabbit, soaking it in a solution with a mixture of saline and estrone and then placing it back in the rabbit. The experiment could not be repeated by other scientists and prompted wide-scale condemnation. It cost him his tenure position at Harvard University. In order to continue his research Pincus helped found the Worcester Foundation for Experimental Biology in 1944, where he led the development of the first contraceptive pill in the early 1950s. 1967-08-22T00:00:00+0000This is achieved by Walter Gilbert and Allan Maxam at Harvard University using a method known as wandering-spot analysis.1973-01-01T00:00:00+0000A.D. Riggs, 'X inactivation, differentiation, and DNA methylation', Cytogenet Cell Genet, 14 (1975), 9–25; R. Sager, R. Kitchin, 'Selective silencing of eukaryotic DNA', Science, 189/4201 (1975), 426-33. 1975-01-01T00:00:00+0000Julian was a chemist who was a renowned pioneer of pharmacological synthesis. He was the first African-American granted a doctoral degree in chemistry and the first to be inducted into the National Academy of Sciences. In 1935 he achieved the first synthesis of physostigmine. This he produced from soybean oil. The drug is used to treat glaucoma and delayed gastric emptying. A year later he joined the Gidden Company in Chicago where he oversaw the development of the industrial large-scale chemical synthesis of the human sex hormones progesterone, oestrogen and testosterone from soybean plant sterols. This work laid the foundation for the industrial production of cortisone, other corticosteroids, and the oral contraceptive pill. Julian left Gidden in 1953 to found his own company, Julian Laboratories Inc.1975-04-19T00:00:00+0000Two separate teams, one led by Fred Sanger at the MRC Laboratory of Molecular Biology, Cambridge, UK, and one composed of Allan Maxam, and Walter Gilbert at Harvard University publish two different methods for sequencing DNA. The first, known as the Sanger Method, or dideoxy sequencing, involves the breaking down and then building up of DNA sequences. The second, the Maxam-Gilbert method, involves the partial chemical modification of nucleotides in DNA. 1977-02-01T00:00:00+0000Fieser was an organic chemist. He won many research awards for his work on blood-clotting agents, including for the synthesis of vitamin K, which he achieved in 1939 and for which he was nominated as a contender for the Nobel Prize in 1941 and 1942 (when no prizes were awarded). His work on steroids also laid the foundation for the synthesis of cortisone. In addition he helped develop quinones as antimalarial drugs. Fieser had two chemical reagents named after him. He is also famous for the creation of napalm, a flammable liquid he developed during World War II, which was controversially used as an incendiary device in the Vietnam war.1977-07-25T00:00:00+0000Woodward was an organic chemist who won the 1965 Nobel Prize in Chemistry for opening up the field of artificial synthesis. He first made his mark in the early 1940s by demonstrating the application of ultraviolet spectroscopy for elucidating the structure of natural products. His method helped reduce the long and extremely tedious steps previously used to decipher the chemical structures of such products. In 1944 he and his postdoctoral researcher, William von Eggers Doering reported the successful synthesis of quinine, an organic compound used for the treatment for malaria. He went on to synthesis other organic compounds like cholesterol, cortisone, strychnine, and chlorophyll.1979-07-08T00:00:00+0000Prize shared with Walter Gilbert. Awarded on the basis of their 'contributions concerning the determination of base sequences in nucleic acids.' 1980-01-01T00:00:00+0000Orr-Weaver, T L, Szostak, J W, Rothstein, R J, 'Yeast transformation: A model system for the study of recombination', PNAS, 78/10 (1981), 6353-8.1981-10-01T00:00:00+0000Lipmann was an American biochemist who shared the 1953 Nobel Prize for Medicine for the discovery of coenzyme A. He made the discovery in 1947 when examining pigeon liver extracts. Coenzyme A is one of the most important substances involved in cellular metabolism. It helps convert amino acids, fatty acids and haemoglobulins into energy.1986-07-24T00:00:00+0000C Doyle, JL Strominger, 'Interaction between CD4 and class II MHC molecules mediates cell adhesion', Nature, 330 (1987), 256-9.1987-11-19T00:00:00+0000USPTO patent 4,736,866 awarded for transgenic mouse with activated oncogenes created by Philip Leder and Timonthy A Stewart at Harvard University. The two scientists isolated a gene that causes cancer in many mammals, including humans, and inserted it into fertilised mouse eggs. The aim was to genetically engineer a mouse as a model for furthering cancer research and the testing of new drugs. It was the first animal ever given patent protection in the USA. 1988-04-12T00:00:00+0000CE Rudd, JM Trevillyan, JD Dasgupta, LL Wong, SF Schlossman, 'The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (Pp58) from human T lymphocytes', Proc Natl Acad Sci USA, 85 (1988), 5190-94.1988-07-01T00:00:00+0000She was supervised by Jack Szostak. Her doctoral research focused on ribozymes. 1989-01-01T00:00:00+0000Wald was an American biologist renowned for his research on how the eye passes images to the brain. He first made his mark in the early 1930s when he discovered that vitamin A was an important component in rhodopsin, a light-sensitive biological pigment found in the rods of the retina. Over the next 30 years he conducted a series of experiments which showed when exposed to light rhodopsin changes its form which triggers signals in a complicated network of optic nerve cells which eventually convert into visual impressions in the brain. In 1967 he was jointly awarded the Nobel Prize for Medicine for 'discoveries concerning the primary physiological and chemical visual processes in the eye.'1997-04-12T00:00:00+0000Porter was a Canadian biologist. He is renowned for having developed many of the techniques and experimental approaches that underpinned the founding of cellular biology as a new discipline in biomedical research. Critically he developed the first electron microscope techniques to get high resolution images of cells and tissues. In 1945 he published the first electron microgragh of a complete animal cell. His other major contributions to the field was his development a roller-flask for culturing cells and helping to invent an instrument for getting ultra-thin slices of tissue for microscopy. 1997-05-02T00:00:00+0000Bloch was a German-American biochemist who shared the 1964 Nobel Prize for Physiology or Medicine for helping to uncover the mechanism and regulation of cholesterol and fatty acid metabolism. This work laid the foundation for understanding the relationship between blood cholesterol levels and atherosclerosis. 2000-10-15T00:00:00+0000A team at Harvard Stem Cell Institute reported fusing adult skin cells with embryonic stem cells to reset the culture so that the cells behave like embryonic stem cells. The researchers did the work using pelvic bone cells as the somatic cells and a different human embryonic cell line. Chad A Cowan, Jocelyn Alenza, Douglas A Melton, Kevin Eggan, 'Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells', Science, 309/5739 (2005), 1369-73. 2005-08-25T00:00:00+0000A Ventura, et al, 'Restoration of p53 function leads to tumour regression in vivo', Nature, 445 (2007), 661-5; W Xue, et al, 'Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas', Nature, 445 (2007), 656–60.2007-01-01T00:00:00+0000A team of scientists led by George Q Daley at the Harvard Stem Cell Institute reported the creation of stem cells for 10 genetic disorders that will enable researchers to watch diseases develop in a lab dish. The researchers used ordinary skin cells and bone marrow from people with a variety of diseases, including Parkinson's, Huntington's and Down syndrome to produce the stem cells. They published their results in I H Park, et al, 'Disease-specific induced pluripotent stem cells', Cell, 134/5 (2008), 877-86.2008-09-05T00:00:00+0000
Date Event People Places Sciences
22 Aug 1967Gregory Pincus diedPincusHarvard University, Worcester Foundation for Experimental BiologyReproduction
1973The sequencing of 24 basepairs is reportedGilbert, MaxamHarvard UniversityDNA Sequencing
1975DNA methylation suggested as mechanism behind X-chomosome silencing in embryosRiggs, Sager, KitchenCity of Hope National Medical Center, Harvard UniversityDNA methylation, Epigenetics, Embryology
19 Apr 1975Percy Lavon Julian diedJulianHarvard UniversityPharmacology, Reproduction
Feb 1977Two different DNA sequencing methods published that allow for the rapid sequencing of long stretches of DNASanger, Maxam, GilbertHarvard University, Laboratory of Molecular BiologyDNA Sequencing
25 Jul 1977Louis F Fieser diedFieserHarvard University 
Jul 1979Robert Burns Woodward diedWoodwardHarvard UniversityPharmacology
1980Sanger awarded his second Nobel Prize in ChemistrySanger, GilbertHarvard University, Laboratory of Molecular BiologyDNA Sequencing
Oct 1981Double-stranded DNA break technique developed for genetically modifying yeast Orr-Weaver, Szostak, RothsteinHarvard University, New Jersey Medical SchoolGene editing
24 Jul 1986Fritz A Lipmann diedLipmannCornell University, Harvard UniversityNutrition
Nov 1987First evidence provided for the interaction between the surface molecule CD4 and major histocompatibility class IIDoyle, StromingerHarvard UniversityImmunology, Cancer immunotherapy, Oncology
12 Apr 1988OncoMouse patent grantedLeder, StewartHarvard UniversityTransgenic animals, Oncology, Recombinant DNA, Gene editing
Jul 1988Biochemical initiators of T Cell activitation, CD4 and CD8-p56, discoveredRudd, Trevillyan, Dasupta, Wong, SchlossmanDana-Faber Cancer Institute, Harvard University, Tech UniversityImmunology, Cancer immunotherapy, Oncology
1989Doudna completed her doctorateDoudnaHarvard University 
12 Apr 1997George Wald diedWaldHarvard University, Occular physiology
2 May 1997Keith Roberts Porter diedPorterHarvard University, University of ColoradoCell
15 Oct 2000Konrad Bloch diedBlochHarvard UniversityBiochemistry
25 Aug 2005Harvard scientists reported reprogramming adult skin cells into embryonic stem cells Cowan, Eggan, Melton, AlienzaHarvard Stem Cell InstituteStem cells
2007p53-induced senescence shown to prevent cancerVentura, Kirsch, McLaughlin, Tuveson, Grimm, Lintault, Newman, Reczek, Weissleder, Jacks, Xue, Zender, Miething, Dickins, Hernando, Krizhanovsky, Cordon-Cardo, LoweMassachusetts Institute of Technology, Massachusetts General Hospital, Harvard University, Howard Hughes Medical Institute, Cold Spring Harbor LaboratoryOncology, p53
5 Sep 2008Scientists created stem cells for 10 disordersDaley, Park, Arora, Huo, Maherall, Ahfedt, Shimamura, Lensch, Cowan, HochedlingerHarvard Stem Cell InstituteStem cells

22 Aug 1967

Gregory Pincus died

1973

The sequencing of 24 basepairs is reported

1975

DNA methylation suggested as mechanism behind X-chomosome silencing in embryos

19 Apr 1975

Percy Lavon Julian died

Feb 1977

Two different DNA sequencing methods published that allow for the rapid sequencing of long stretches of DNA

25 Jul 1977

Louis F Fieser died

25 Jul 1977

Robert Burns Woodward died

1980

Sanger awarded his second Nobel Prize in Chemistry

Oct 1981

Double-stranded DNA break technique developed for genetically modifying yeast

24 Jul 1986

Fritz A Lipmann died

Nov 1987

First evidence provided for the interaction between the surface molecule CD4 and major histocompatibility class II

12 Apr 1988

OncoMouse patent granted

Jul 1988

Biochemical initiators of T Cell activitation, CD4 and CD8-p56, discovered

1989

Doudna completed her doctorate

12 Apr 1997

George Wald died

2 May 1997

Keith Roberts Porter died

15 Oct 2000

Konrad Bloch died

25 Aug 2005

Harvard scientists reported reprogramming adult skin cells into embryonic stem cells

2007

p53-induced senescence shown to prevent cancer

5 Sep 2008

Scientists created stem cells for 10 disorders