Pasteur Institute: Timeline of key events

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F Galibert, E Mandart, F Fitoussi, P Tiollais, P Charnay, , 'Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature, 281/5733 (1979), 646-50; P. Charnay, C Pourcel, A Louise, A Fritsch, P Tiollais, 'Cloning in Escherichia coli and physical structure of hepatitis B virion DNA', PNAS USA, 76/5 (1979), 2222-26; P Charnay, E Mandart, A Hampe, F Fitoussi, P Tiollais, F Galibert, 'Localization on the viral genome and nucleotide sequence of the gene coding for the two major polypeptides of the hepatitis B surface antigen (HBs Ag)', Nucleic Acids Research, 7/2 (1979), 335-46.1979-05-01T00:00:00+00001980-01-01T00:00:00+0000The vaccines were made with HBsAg purified from plasma of people with chronic hepatitis B. The vaccines were Hevac B Pasteur - made by Merieux and the Pasteur Institute and Hepatavax made by Maurice Hilleman at Merck.1982-01-01T00:00:00+00001989-05-01T00:00:00+0000Lwoff was a microbiologist. He shared the 1965 Nobel Prize for Medicine for 'discoveries concerning genetic control of enzyme and virus synthesis'. This was based on work he carried out in the early 1950s to understand lysogeny. This is the process by which some the genes of some viruses, bacteriophages (phage), get incorporated into the genetic material of a bacteria but remain latent until the formation of a new phage triggered by a particular event. He found that exposure to ultraviolet light was one factor that could spur on the development a new phage. Lwoff also discovered that vitamins help promote growth in microbes and can serve as co-enzymes. 1994-09-30T00:00:00+0000
Date Event People Places Sciences
May 1979 - Oct 1979Pasteur Institute scientists reported successful cloning of hepatitis B DNA in Escherichia coliGalibert, Mandart, Fitoussi, Tiollais, Charnay, HampePasteur InstituteRecombinant DNA, Vaccine
1980Pasteur Institute filed for US patent for fractionation method to purify HBsAg from plasma to produce hepatitis B vaccineTiollaisPasteur InstituteVaccine
1982First plasma vaccines against hepatitis B licensed for market in US and EuropeHillemanMerieux, Institute Pasteur, MerckVaccine
May 1989Genetically engineered hepatitis B vaccine, GenHevac, approved in France Pasteur VaccinsVaccine, Recombinant DNA
30 Sep 1994Andre Michel Lwoff diedLwoffPasteur InstituteMicrobiology, Virology

May 1979 - Oct 1979

Pasteur Institute scientists reported successful cloning of hepatitis B DNA in Escherichia coli

1980

Pasteur Institute filed for US patent for fractionation method to purify HBsAg from plasma to produce hepatitis B vaccine

1982

First plasma vaccines against hepatitis B licensed for market in US and Europe

May 1989

Genetically engineered hepatitis B vaccine, GenHevac, approved in France

30 Sep 1994

Andre Michel Lwoff died