CRISPR-Cas9: Timeline of key events

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Kleinstiver, B P, Pattanayak, V, Prew, M S, Tsai, S Q, Nguyen, N T, Zheng, Z, Joung, K, 'High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects', Nature, doi:10.1038.2016-01-06T00:00:00+0000The UK Human Fertilisation and Embryology Authority give the go ahead to a team at the Crick institute, led by Kathy Nikan, to edit human embyos to undestand the genetic cause of miscarriage. 2016-02-01T00:00:00+0000Work led by Carl June at University of Pennsylvannia to treat patients with multiple myeloma, melanoma and sarcoma.2016-06-21T00:00:00+0000NAS and NAM, Human Genome Editing: Science, Ethics and Governance, February 20172017-02-24T00:00:00+0000J. S. Gootenberg, O.O. Abudayyeh, J. W. Lee, et al, 'Nucleic acid detection with CRISPR-Cas13a/C2c2', Science, 13 April 2017, eaam9321, DOI: 10.1126/science.aam9321 2017-04-13T00:00:00+0000The experiment was carried out by scientists at Sichuan University, Temple University and the University of Pittsburgh. It was published in C. Yin, et al, 'In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models', Molecular Therapy, 25/5 (2017), 1168-86.2017-05-13T00:00:00+0000M. Hong, N. Marti-Gutierrez, S-W Park, et al, 'Correction of a pathogenic gene mutation in human embryos', Nature, doi:10.1038/nature233052017-08-02T00:00:00+0000
Date Event People Places Sciences
6 Jan 2016Harvard scientists published improved version of CRISPR/Cas 9 with less risk of off-target DNA breaksKleinstiver, Pattanayak, Prew, Tsai, Nguyen, Zheng, JoungHarvard UniversityCRISPR-Cas9, Gene editing
1 Feb 2016UK scientists authorised to genetically modify human embryos using CRISPR-Cas 9NiakanCrick InstituteCRISPR-Cas9
21 Jun 2016US NIH Recombinant DNA Advisory Committee approved first study in 15 patients using CRISPR/Cas 9 to genetically modify immune cells to attack cancerJuneUniversity of PennsylvaniaCRISPR-Cas9, Gene editing, Gene Cancer immunotherapy
Feb 2017US National Academies of Science and Medicine issue report saying possible to proceed with CRISPR in germ-line experiments but urge caution  CRISPR-Cas9, Gene editing
13 Apr 2017CRISPR shown to be sensitive diagnostic tool for detecting single target of DNA or RNA moleculeAbudayyeh, Bhattacharyya, Collins, Daringe, Donghia, Dy, Essletzbichler, Freije, Hung, Joung, Koonin, Lee, Livny, Myhrvold, Regev, Sabeti, Gootenberg, Verdine, ZhangBroad Institute, Massachusetts Institute of Technology, Harvard University, Howard Hughes Medical Institute CRISPR-Cas9, Gene editing
13 May 2017Research published demonstrating how CRISPR-CAS9 can be used to eliminate HIV in infected mice. Yin, Zhang, Qu, Chang, Putatunda, Xiao, Li, Zhao, Dhai, Qin, Mo, Young, Khalili, HuTemple University, University of Pittsburgh, Sichuan UniversityCRISPR-Cas9, Gene editing
2 Aug 2017Research published demonstrating possibility of editing gene defect in pre-implanted human embryos for preventing inherited heart diseaseHong, Marti-Gutierrez, Park, Mitalipov, Kaul, Kim, Amato, BelmonteOregon Health & Science University, Salk Institute, Center for Genome Engineering, Seoul National University, China National GeneBank,CRISPR-Cas9, Reproduction, Cardiovascular, Gene editing

6 Jan 2016

Harvard scientists published improved version of CRISPR/Cas 9 with less risk of off-target DNA breaks

1 Feb 2016

UK scientists authorised to genetically modify human embryos using CRISPR-Cas 9

21 Jun 2016

US NIH Recombinant DNA Advisory Committee approved first study in 15 patients using CRISPR/Cas 9 to genetically modify immune cells to attack cancer

Feb 2017

US National Academies of Science and Medicine issue report saying possible to proceed with CRISPR in germ-line experiments but urge caution

13 Apr 2017

CRISPR shown to be sensitive diagnostic tool for detecting single target of DNA or RNA molecule

13 May 2017

Research published demonstrating how CRISPR-CAS9 can be used to eliminate HIV in infected mice.

2 Aug 2017

Research published demonstrating possibility of editing gene defect in pre-implanted human embryos for preventing inherited heart disease