Genetics: Timeline of key events

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2012-09-28T00:00:00+0000Ruddle helped pioneer human gene mapping and established many of the techniques and a framework for setting up the Human Genome Project. He is also known for having generated, with Jon W. Gordon and George Scango the first successful transgenic mouse. His work heralded the development of genetically modified animals as research models to investigate the function of genes and genetic cause of disease. He also co-discovered, with William McGinnis, the first human homeobox genes, important regulators of gene development. 2013-03-10T00:00:00+0000Jacob shared the 1965 Nobel Prize for Medicine for 'discoveries concerning genetic control of enzyme and virus synthesis.' 2013-04-19T00:00:00+00002015-04-01T00:00:00+0000K.B. Chiappinelli, P.L. Strissel, A. Desrichard, et al, 'Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses', Cell, 162 (2015), 974-86.2015-08-27T00:00:00+0000Griffin was a leading expert on viruses that cause cancer. First woman appointed to Royal Postgraduate Medical School, Hammersmith Hospital. In 1980 she completed the sequence of the poliovirus, the longest piece of eukaryotic DNA to be sequenced at that time. Devoted her life to understanding the Epstein-Barr virus, the cause of Burkitt's Lymphoma, a deadly form of cancer. 2016-06-13T00:00:00+0000Discovery made as a result of study of 177 members of the Old Order of Amish community in Indiana. S. Khan, et al, 'A null mutation in SERPINE1 protects against biological aging in humans', Science Advances, 3/11 (2017), DOI: 10.1126/sciadv.aao16172017-11-15T00:00:00+0000
Date Event People Places Sciences
2012European approval of decatabine (Dacogen) for treatment of acute myeloid leukaemia  Epigenetics, Oncology
10 Mar 2013Frank Ruddle died in New Haven, ConnecticutRuddleYale UniversityGenetics, Transgenic, Cloning
19 Apr 2013Francois Jacob diedJacobPasteur InstituteGenetics
Apr 2015Chinese regulatory authorities approved Chidamide, a histone deactylase inhibitor, for peripheral T cell lymphoma  Epigenetics, Oncology
27 Aug 2015Experiments with mice showed that azacytidine treatment enhanced the responsiveness of tumors to anti–CTLA-4 therapy  Cancer immunotherapy, Epigenetics, Immune checkpoint inhibitors, Oncology
13 Jun 2016Beverly Griffin diedGriffinImperial CollegeDNA sequencing, genetics
15 Nov 2017Rare mutation of gene called Serpine 1 discovered to protect against biological ageing processKhan, Shah, Klyachko, Baldridge, Eren, Place, Aviv, Puterman, Lloyd-Jones, Heiman, Miyata, Gupta, Shapiro, VaughanNorthwestern University, University of British Columbia, New Jersey Medical School, Tohoku University, DNA sequencing, Genetics, Genomics

2012

European approval of decatabine (Dacogen) for treatment of acute myeloid leukaemia

10 Mar 2013

Frank Ruddle died in New Haven, Connecticut

19 Apr 2013

Francois Jacob died

Apr 2015

Chinese regulatory authorities approved Chidamide, a histone deactylase inhibitor, for peripheral T cell lymphoma

27 Aug 2015

Experiments with mice showed that azacytidine treatment enhanced the responsiveness of tumors to anti–CTLA-4 therapy

13 Jun 2016

Beverly Griffin died

15 Nov 2017

Rare mutation of gene called Serpine 1 discovered to protect against biological ageing process