Virology: Timeline of key events

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Temin shared the 1975 Nobel Prize for Medicine for work on the interactions between tumour viruses and the genetic material of the cell. 1934-12-10T00:00:00+0000Bishop is an immunologist and microbiologist. He shared the 1989 Nobel Prize for Medicine with Harold E Varmus for discovering the first human oncogene, c-Src. Oncogenes are a type of gene that in certain circumstances, such as exposure to chemical carcinogens, can change a normal cell into a tumour cell. Bishop and Varmus made the discovery while working with the Rouse sarcoma virus known to cause cancer in chickens. 1936-02-22T00:00:00+0000Baltimore shared the 1975 Nobel Prize for his work on the interaction between tumor viruses and the genetic material of the cell. He also spearheaded efforts for the scientific governance of recombinant DNA and genome editing technologies. 1938-03-07T00:00:00+0000Barré-Sinoussi shared the Nobel Prize for Medicine in 2008 for the discovery of HIV.1947-07-30T00:00:00+0000d'Herelle was a French Canadian microbiologist who co-discovered bacteriophages (phages), viruses that infect bacteria that are now major tools in biotechnology. He isolated the first phage from chicken faeces in 1919. Following this he successfully treated chicken affected by a plague of typhus with the phage and in August 1919 cured a patient with dysentery using the same method. This laid the basis for the development of phage therapy. 1949-02-22T00:00:00+0000The first polio vaccine, developed by Jonas Salk, was tested on children from Arsenal Elementary School in Pittsburg, Pennsylvania. Nearly 2 million children in 44 states were tested. The trial showed the vaccine to be effective. The vaccine radically reduced the number of polio victims around the world.1954-02-23T00:00:00+0000Goodpasture developed a method of culturing viruses in chicken embryos and fertilized chicken eggs. Before this viruses were grown in living tissues which could be contaminated by bacteria. Goodpasture's method laid the foundation for the development of vaccines for smallpox, yellow fever, typhus and chicken pox.1960-09-20T00:00:00+0000Created by Leonard Hayflick and Paul S Moorhead.1962-01-01T00:00:00+0000Developed by Samuel Katz and John F Enders, the vaccine would later be incorporated into the MMR, a combination vaccine against measles, mumps and rubella.1963-01-01T00:00:00+0000The vaccine was made by Maurice Hilleman using material taken from his daughter, Jeryl Lynn, when she suffered measles. The Jeryl strain of the mumps vaccine is still in use today and used in the MMR vaccine.1963-01-01T00:00:00+0000LJ Old, EA Boyse, E Oettgen, ED Harven, ED Geering, B Williamson, P Clifford, 'Precipitating antibody in human serum to an antigen present in cultured Burkitt's lymphoma cells', Proc Natl Acad Sci USA, 56 (1966), 1699–1704.1966-12-01T00:00:00+0000The vaccine, RA27/3 had been developed by a team headed by Stanley Plotkin.1969-01-01T00:00:00+0000Stanley was an American biochemist and virologist. In 1935 he managed to crystalise the tobacco virus, the causative agent of plant disease. This was a major breakthrough because prior to this no scientists had succeeded in finding out what viruses were. His work laid the foundation for other scientists, using x-ray diffraction, to work out the precise molecular structures and reproduction process of several viruses. During World War II he managed to purify several of the most common influenza viruses and developed a vaccine that was partly effective. In 1946 he shared the Nobel Prize for Chemistry for the 'preparation of enzymes and virus proteins in a pure form.' 1971-06-15T00:00:00+0000An American pathologist, Rous won the 1966 Nobel Prize for showing how viruses could cause cancer. He demonstrated this in 1910 by transplanting some material from a cancer tumour taken from a chicken into a healthy chicken. The healthy chicken developed cancer. Other scientists struggled to replicate his experiment in mammals so his discovery was initially dismissed. 1972-02-16T00:00:00+0000The vaccine was developed by Stanley Plotkin, Hilary Koprowski and Tadeusz Wiktor at the Wistar Institute1980-01-01T00:00:00+0000A German biophysicist, Delbruck helped discover how viruses replicate their genetic structure, showing that bacterial resistance from viruses is due to random mutation and not the result of adaptive changes. In 1969 he was awarded the Nobel Prize for Medicine on the back of this work. 1981-03-09T00:00:00+0000The work opened up the possibility of sequencing the virus. It was published in J R Arrand, L. Rymo, J E Walsh, E Bjorck, T Lindahl and B E Griffin, ‘Molecular cloning of the complete Epstein-Barr virus genome as a set of overlapping restriction endonuclease fragments’, Nucleic Acids Research, 9/13 (1981), 2999-2014.1981-07-10T00:00:00+0000Based on investigation of blood drawn from AIDS patients who developed Kaposi sarcoma, a cancer caused by a virus. The research was carried out by Susan Krown and Bijan Safai.1983-01-01T00:00:00+0000M Durst, L Gissmann, H Ikenberg, H zur Hausen, 'A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions', Proc Natl Acad Sci USA, 80 (1983), 3812-15.1983-06-01T00:00:00+0000An American microbiologist, Enders shared the 1954 Nobel Prize for helping to develop a technique to grow the poliomyeltitis virus, paving the way to a vaccine against polio. 1985-09-08T00:00:00+0000
Date Event People Places Sciences
10 Dec 1934Howard M Temin was born in Philadelphia PA, USATeminUniversity of WisconsinGenetics, Virology, Oncology
Feb 1936John Michael Bishop born in York PA, USABishopUniversity California San FranciscoOncology, Virology
7 Mar 1938David Baltimore was born in New York CityBaltimoreNew York CityRecombinant DNA, Oncology, Virology, Cloning
30 Jul 1947Francoise Barré-Sinoussi born in Paris, FranceBarre-SinoussiParis, FranceVirology
22 Feb 1949Felix d'Herelle diedd'HerellePasteur InstituteAntibacterial agents, Bacteriophages, Bacteriology, Virology
23 Feb 1954Salk polio vaccine trial begunSalkUniversity of PittsburghVirology, Vaccine
20 Sep 1960Ernest Goodpasture diedGoodpastureHarvard UniversityVirology, Vaccine
1962WI-38 cell line developed - important to development of vaccinesHayflick, MoorheadWistar InstituteVaccine, Virology
1963 - 1963Development of first attentuated measles virus vaccineEnders, Katz Vaccine, Virology
1963Creation of first vaccine against mumpsHillemanMerck & CoVaccines, Virology
Dec 1966Scientists detect antibodies to the Epstein-Barr virus in patients with nasopharyngeal cancer which suggest the cancer is caused by a virus. Old, Boyse, OettgenMemorial Sloan Kettering Cancer CenterCancer immunotherapy, Oncology, Virology
1969 - 1970First license approved in US and Europe for vaccine against rubella (German measles)PlotkinWistar InstituteVaccine, Virology
15 Jun 1971Wendell M Stanley diedStanleyRockefeller InstituteBiochemistry, Virology, Vaccine
16 Feb 1972Francis Peyton Rous diedRousRockefeller UniversityVirology, Oncology
1980US licensed first rabies vaccine for human useKoprowski, Plotkin, WiktorWistar InstituteVaccine, Virology
9 Mar 1981Max Delbruck diedDelbruckCalifornia Institute of TechnologyGenetics, Virology
10 Jul 1981Complete library of overlapping DNA fragments of Epstein Barr Virus clonedGriffin, Arrand, Walsh, Bjorck, RymoImperial Cancer Research Fund Laboratories, University of GothenbergRecombinant DNA, Oncology, Virology, Cloning
1983Link drawn between immune deficiency and cancer  Memorial Sloan Kettering Cancer CenterImmunology, Oncology, Virology
Jun 1983Harald Zur Hausen identifies the human papillomavirus as the causative agent of cervical cancerzur HausenUniversity of FreibergOncology, Virology
8 Sep 1985John F Enders diedEndersChildren's Hospital BostonVirology, Vaccine

10 Dec 1934

Howard M Temin was born in Philadelphia PA, USA

10 Dec 1934

John Michael Bishop born in York PA, USA

7 Mar 1938

David Baltimore was born in New York City

30 Jul 1947

Francoise Barré-Sinoussi born in Paris, France

22 Feb 1949

Felix d'Herelle died

23 Feb 1954

Salk polio vaccine trial begun

20 Sep 1960

Ernest Goodpasture died

1962

WI-38 cell line developed - important to development of vaccines

1963 - 1963

Development of first attentuated measles virus vaccine

1963

Creation of first vaccine against mumps

Dec 1966

Scientists detect antibodies to the Epstein-Barr virus in patients with nasopharyngeal cancer which suggest the cancer is caused by a virus.

1969 - 1970

First license approved in US and Europe for vaccine against rubella (German measles)

15 Jun 1971

Wendell M Stanley died

16 Feb 1972

Francis Peyton Rous died

1980

US licensed first rabies vaccine for human use

9 Mar 1981

Max Delbruck died

10 Jul 1981

Complete library of overlapping DNA fragments of Epstein Barr Virus cloned

1983

Link drawn between immune deficiency and cancer

Jun 1983

Harald Zur Hausen identifies the human papillomavirus as the causative agent of cervical cancer

8 Sep 1985

John F Enders died