The role of women in biotechnology
Often hidden from view, women have played a major role in the development of biotechnology and medicine. Indeed, women have been at the cutting edge of biotechnology, including Rosalind Franklin who played a fundamental role in deciphering the structure of DNA; Esther Lederberg who discovered the lambda phage which is now a major tool for studying gene regulation and genetic recombination; Margaret Dayhoff who developed the field of bioinformatics; Janet Mertz who created the first piece of recombinant DNA; and Jennifer Doudna and Emmanuelle Charpentier who helped pioneer CRISPR, a revolutionary technique for genome editing.
Here we provide a number of profiles of women who have been key pioneers in biotechnology. These profiles have been compiled as part of an ongoing project to highlight the many contributions women have made to biotechnology. This is a work in progress and we welcome suggestions for other women to be included.
Some of the leading women in biotechnology
Don't hesitate to contact us if you think of other women who have played an important role in the development of biotechnology and who are not here.
Brigitte Askonas (1923 - 2013)
Born: Vienna, Austria. Askonas co-developed one of the first systems for the cloning of antibody-forming B cells in vivo, some of the earliest monoclonal antibodies. She was also one of the first scientists to isolate and clone virus specific T lymphocytes, laying the foundation for defining different influenza sub-sets and improving vaccines. (Photo credit: Anne-Katrin Purkiss, Wellcome Images B0007461).
Margaret Dayhoff (1925 - 1983)
Born: Philadelphia, Pennsylvania, United States. Dayhoff is known as the founder of bioinformatics. This she did by pioneering the application of mathematics and computational techniques to the sequencing of proteins and nucleic acids and establishing the first publicly available database for research in the area. (Photo credit: Ruth E Dayhoff, National Library of Medicine).
Jennifer Doudna (1964)
Born: Washington DC, United States. Doudna first made her name uncovering the basic structure and function of the first ribozyme, a type of catalytic ribonucleic acid (RNA) that helps catalyse chemical reactions. This work helped lay the foundation for her later helping to pioneer CRISPR-Cas 9, a tool that has provided the means to edit genes on an unprecedented scale and at minimal cost. In addition to her scientific contributions to CRISPR, Doudna is known for spearheading the public debate to consider the ethical implications of using CRISPR-Cas9 to edit human embryos.
Rosalind Franklin (1920 - 1958)
Born: London, United Kingdom. Rosalind Franklin was an x-ray crystallographer whose work helped uncover the double-helix structure of DNA. (Photo credit: Vittorio Luzzati).
Esther Lederberg (1922 - 2006)
Born: Bronx, New York, United States. Esther Lederberg was a major pioneer of bacterial genetics. She discovered the lambda phage, a bacterial virus which is widely used as a tool to study gene regulation and genetic recombination. She also invented the replica plating technique, which is used to isolate and analyse bacterial mutants and track antibiotic resistance. (Photo credit: The Esther Lederberg Memorial Trust).
Rita Levi-Montalcini (1909 - 2012)
Born: Turin, Italy. An Italian scientist, Rita Levi-Montalcini helped discover the chemical tools the body uses to direct cell growth and build nerves. This knowledge underpins current investigation into how these processes go wrong in diseases like dementia and cancer. (Photo credit: Bernard Becker Medical Library).
Janet Mertz (1949)
Born: The Bronx, New York, USA. Mertz was pivotal to the discovery of the first enzyme for easily joining together DNA from different species and designing the protocol that underpinned the development of the first recombinant DNA cloned in bacteria. Her work not only helped lay the foundation for the development of genetic engineering, but also spurred on the establishment of the first safety guidelines for laboratories involved in genetic manipulation. She has also made key contributions to our understanding about how the human tumour viruses SV40, hepatitis B virus, and Epstein-Barr virus regulate expression of their genes and identified roles oestrogen-related receptors play in breast cancer and responses to therapies. (Photo credit: Janet Mertz).
Rosemary Versteegen (1948)
Born: Glasgow, Scotland. Rosemary J Versteegen worked for over twenty years with Life Technologies Inc, which in the 1990s was one of largest suppliers of culture cell products and other scientific reagents to the biotechnology industry. She was pivotal to the company’s success in winning FDA approval for the first diagnostic test using synthetic nucleic acid probes for detecting infection with the human papillomavirus, one of the most common causes of cervical cancer. In addition, Versteegen is one of the co-founders and the Chief Executive Officer of the International Serum Industry Association, an organisation that works to promote standards of excellence and ethics in the animal serum and animal derived products industry.
Francoise Barre-Sinoussi (1947)
Born: Paris, France. Barre-Sinoussi shared the 2008 Nobel Prize in Physiology or Medicine for helping to identify the human immunodeficiency virus (HIV) as the cause of AIDS in 1983. Over the years she has made substantial contributions to understanding the role of innate immune defences in the host in controlling HIV/AIDS and how HIV is transmitted between the mother and child. She has also studied the characteristics that allow some HIV-positive individuals gain resistance to HIV without antiretrioviral drugs. (Photo credit: Karolinska Institute, Press conference, 2008).
Elizabeth Blackburn (1948)
Born: Hobart, Tasmania, Australia. Blackburn is a molecular biologist who was awarded the Nobel Prize in Physiology or Medicine in 2009. She is best known for having discovered a particular repetative sequence of DNA on the telomere, a particular region found at the end of a chromosome that prevents the chromosome ends from fraying and sticking to each other. She also helped identify telomerase, an enzyme that helps replenish telomeres which get shorter every time a cell divides. Such shortening is associated with aging and cancer. (Photo credit: Chemical Heritage Foundation).
Gertrude Elion (1918 - 1999)
Born: New York City, United States. Elion shared the 1988 Nobel Prize in Physiology or Medicine for her contributions to the development of a multitude of new drugs. This included drugs for herpes, leukemia, malaria, gout, immune disorders, and AIDS, and immune suppressants to overcome rejection of donated organs in transplant surgery. Her work earned 45 patents. (Photo credit: Wellcome Images).
Carol Greider (1961)
Born: San Diego, California, United States. Greider shared the Nobel Prize for Physiology or Medicine in 2009 for helping to elucidate the structure of telomeres, a particular region found at the end of a chromosome that prevents the chromosome ends from fraying and sticking to each other, and to identify telomerase, an enzyme that helps replenish telomeres which get shorter every time a cell divides. Such shortening is associated with aging and cancer. She also collaborated in the development of the first telomerase knockout mouse which helped demonstrate how premature aging is linked to increasingly short telomeres. (Photo credit: Keith Weller).
Beverly Griffin (1930 - 2016)
Born: Dehli, Louisiana. Griffin completed the first DNA sequence of the polyomavirus in 1980. Known to cause cancer in mice, the virus was the longest piece of eukaryotic DNA to be sequenced for the time. She also cloned the first DNA fragments from the Epstein-Barr virus (EBV), which provided the starting point for its sequencing, completed in 1984. For the remainder of her career Beverly was devoted to understanding how in one setting EBV could cause glandular fever, a largely harmless disease, and yet in another Burkitt's Lymphoma, a deadly killer in Central Africa. (Photo credit: Tomas Lindahl).
Ingeborg Hochmair-Desoyer (1953)
Born: Vienna, Austria. Hochmair-Desoyer is an electrical engineer who helped create the world's first micro-electric multi-channel cochlear implant. Developed in 1977 the implant enables the user to not only hear sounds but also to understand speech. Since 2000 she has co-founded a number of medical device companies working to help with hearing loss. In 2013 she was awarded the Lasker-DeBakey Clinical Medical Research Award. (Photo credit: Ingeborg J Hochmair-Desoyer).
Dorothy Hodgkin (1910 - 1994)
Born: Cairo, Egypt. Dorothy Hodgkin, was a British biochemist who developed protein crystallography and X-ray crystallography which was used to confirm the structure of penicillin, for which she won the Nobel Prize in Chemistry in 1964. (Photo credit: Peter Lofts Photography, National Portrait Gallery, London Peter Lofts Photography, National Portrait Gallery, London ).
Mary-Claire King (1946)
Born: Illinois, United States. King is a human geneticist who studies the interplay between genetics and the environment on human disease. She is best known for having identified BRCA1, a single gene responsible for many breast and ovarian cancers. Her technique for identifying the BRCA1 gene is now used for studying many other diseases. She was also responsible for the development of a technique, using mitrochondial DNA and human leukocyte antigen, for genetically identifying the remains of missing people. (Photo credit: Mary-Claire King).
Born: United States. A key pioneer in the development of antibody engineering techniques, Morrison helped develop some of the first chimeric monoclonal antibodies. This work paved the way to the creation of safer and more effective monoclonal antibody drugs. (Photo credit: Sherie Morrison).
May-Britt Moser (1963)
Born: Fosnavag, Norway. Moser shared the 2014 Nobel Prize in Physiology or Medicine for helping to discover cells located in the centre of the brain that are important for determining spacial position. Her work has helped scientists gain new understanding into the cognitive processes and spacial deficits linked to neurological conditions like Alzheimer's disease. (Photo credit: NBC News).
Evelyn Witkin (1921)
Born: New York City, United States. Witkin is an American geneticist who is best known for her work on DNA mutagenesis and DNA repair. She helped elucidate the first co-ordinated stress response. This she did studying the response of bacteria to UV radiation. Witkins was one of the first few women to be elected to the US National Academy of Sciences, in 1977 and in 2002 was awarded the National Medal of Science. (Photo credit: YouTube).
Rosalyn Yalow (1921 - 2011)
Born: New York City, United States. The second American woman to ever be awarded the Nobel Prize for Physiology or Medicine, Yalow is best known for having co-developed a diagnostic technique, known as a radioimmunoassay, for measuring tiny quantities of various biological samples in blood and other bodily fluids. The test's primary detection mechanism is an antibody combined with a radioisotope. First devised for determining insulin levels in diabetes patients, the technique is now used for hundreds of other substances previously difficult to detect because they were too small. Among the substances it can quantify are hormones, vitamins, enzymes. It is also used to measure the effectiveness of dose levels of antibiotics and other drugs. (Photo credit: US Information Agency).
Tu Youyou (1930)
Born: Zhejiang, China. Tu Youyou is a Chinese chemist who discovered artemisinin and dihydroartemisinin, used to treat malaria. YouYou received the 2015 Nobel Prize in Physiology or Medicine jointly with William Campbell and Satoshi Omura. Youyou is the first Chinese Nobel laureate in physiology or medicine and the first female citizen of the People's Republic of China to receive a Nobel Prize in any category. (Photo credit: Bengt Nyman).
Women in biotechnology: timeline of key events
|7 Nov 1867||Marie Curie, nee Sklodowska, who won the Nobel Prize for Chemistry in 1911, was born in Warsaw, Russian Empire (now Poland)||Curie||Warsaw|
|16 Jun 1902||Barbara McClintock was born in Hartford CT, USA||McClintock||University of Missouri|
|22 Apr 1909||Rita Levi-Montalcini was born in Turin, Italy||Levi-Montalcini||Institute of Cell Biology of the CNR|
|10 May 1910||Dorothy M Crowfoot Hodgkin was born in Cairo, Egypt||Hodgkin||Cairo, Egypt|
|19 Sep 1915||Elizabeth S Shankman was born in Cobalt, Ontario, Canada||Shankman||University of California at Los Angeles|
|23 Sep 1917||Asima Chatterjee was born in Bengal, India||Chatterjee||University of Calcutta|
|23 Jan 1918||Gertrude B Elion was born in New York NY, USA||Elion||Wellcome Research Laboratories|
|25 Jul 1920||Rosalind E Franklin was born in London, United Kingdom||Franklin||Kings College London|
|9 Mar 1921||Evelyn Witkin was born in New York City, USA||Witkin||New York City|
|19 Jul 1921||Rosalyn Yalow was born in New York NY, USA||Yalow||Veterans Administration Hospital|
|18 Dec 1922||Esther Lederberg was born in Bronx, New York, USA||Lederberg||Wisconsin University|
|1 Apr 1923||Brigitte Askonas was born in Vienna, Austria||Askonas||Vienna|
|11 Mar 1925||Margaret Dayhoff was born in Philadelphia, Pennsylvania, USA||Dayhoff||Philadelphia|
|23 Jan 1930||Beverly Griffin was born in Dehli, Louisiana, USA||Griffin||Imperial College|
|30 Dec 1930||Tu Youyou was born in Zhejiang, China||Youyou||Zhejiang|
|4 Jul 1934||Marie Curie died||Curie|
|27 Feb 1946||Mary-Claire King was born in Illinois, USA||King||Illinois|
|30 Jul 1947||Francoise Barré-Sinoussi born in Paris, France||Barre-Sinoussi||Paris, France|
|1952||First observation of the modification of viruses by bacteria||Luria, Human||University of Illinois|
|January 1952||X-ray diffraction image, produced by Rosalind Franklin, shows DNA to have regularly repeating helical structure||Franklin||Kings College London|
|1 Jan 1953||Ingeborg Hochmair-Desoyer was born in Vienna, Austria||Hochmair-Desoyer||Vienna, Austria|
|April 1953||Franklin's x-ray image of DNA published||Franklin||Kings College London|
|17 Mar 1956||Irène Joliot-Curie died||Curie|
|16 Apr 1958||Rosalind E Franklin died||Franklin||Kings College London|
|15 Apr 1961||Carol W Greider was born in San Diego CA, USA||Greider||Johns Hopkins University|
|16 Dec 1961||First successful direct incorporation of functional DNA in human cell||Kraus||University of Tennessee|
|1962||Concept of restriction and modification enzymes born||Arber, Dussoix||University of Geneva|
|1965||Atlas of Protein Sequence and Structure published||Dayhoff||National Biomedical Research Foundation|
|1970 - 1972||Means developed for cloning B cells that produce single antibodies with known specificity||Askonas, Williamson, Wright||National Institute for Medical Research|
|1971||First plasmid bacterial cloning vector constructed||Berg, Mertz, Jackson||Stanford University|
|June 1971||First time potential biohazards of recombinant DNA raised||Mertz, Berg, Pollack||Stanford University|
|December 1971||First experiments published demonstrating the use of restriction enzymes to cut DNA||Danna, Nathans||Johns Hopkins University|
|November 1972||First easy-to-use technique published for constucting recombinant DNA. J. Mertz, R. Davis, Proceedings of the National Academy of Science, USA 69/11, pp. 2270-74.||Berg, Mertz||Stanford University Medical School|
|1980 - 1990||Existence of the blood stem cell is debated||Dexter, Lord, Weissmann, Morrison|
|18 Aug 1980||Elizabeth Stern Shankman died||Shankman||University of California at Los Angeles|
|September 1980||First DNA sequence database created||Dayhoff||National Biomedical Research Foundation|
|1980||Largest nucleic acid sequence database in the world made available free over telephone network||Dayhoff||National Biomedical Research Foundation|
|5 Feb 1983||Margaret Dayhoff died in Silver Spring, Maryland, USA||Dayhoff||Silver Spring, Maryland|
|1984||First chimeric monoclonal antibodies developed which lays foundation for safer and more effective monoclonal antibody therapeutics||Neuberger, Rabbitts, Morrison, Oi, Herzenberg, Boulianne, Schulman, Hozumi||Laboratory of Molecular Biology, Stanford Univerity Medical School|
|2 Sep 1992||Barbara McClintock died||McClintock||University of Missouri|
|27 Jul 1994||Dorothy Crowfoot Hodgkin died||Hodgkin||Shipston-on-Stour, Warwickshire, UK|
|29 Jul 1994||Dorothy M Crowfoot Hodgkin died||Hodgkin||Oxford University|
|1996||First reports that blood stem cell might be able to give rise to cells other than those of the blood system||Blau, Lagasse, Lemischka, Morrison, Thiese, Krause, Gussoni, Bjornson|
|21 Feb 1999||Gertrude B Elion died||Elion||Wellcome Research Laboratories|
|11 Nov 2006||Esther Lederberg died||Lederberg||Wisconsin University|
|22 Nov 2006||Asima Chatterjee, an Indian organic chemist, died||Chatterjee||University of Calcutta|
|30 May 2011||Rosalyn Yalow died||Yalow||Veterans Administration Hospital|
|May 2012||First patent application submitted for CRISPR-Cas 9 technology||Doudna, Charpentier||University of California Berkeley, University of Vienna|
|August 2012||A group of scientists based at Howard Hughes Medical Institute published a radically new gene editing method that harnessed the CRISPR-Cas9 system||Jinek, Chylinski, Fonfara, Hauer, Doudna, Charpentier||University of California Berkeley|
|30 Dec 2012||Rita Levi-Montalcini died||Levi-Montalcini||Institute of Cell Biology of the CNR|
|9 Jan 2013||Brigitte Askonas died in London, United Kingdom||Askonas||London, United Kingdom|
|5 Oct 2015||Tu Youyou awarded the Nobel Prize in Physiology or Medicine for the discovery of artemisinin, a treatment for malaria||Youyou|
|13 Jun 2016||Beverly Griffin died||Griffin||Imperial College|